Cervical Cancer – its Cause, Sign, Symptoms Diagnosis, Treatment and Life Expectancy

According to World Health Organization, Cervical cancer is the fourth most common cancer in women globally. The highest rates of cervical cancer and mortality due to cervical cancer is seen in low- and middle-income countries. Almost 85 percentage of incidence and death occurs in these countries. Cervical cancer is caused by persistent infection with different stains of the human papillomavirus (HPV). Cervical cancer can be cured if diagnosed at an early stage and treated well.

Cervix is the part of women genital organ between the Uterus and Vagina. It is composed of mainly fibrous connective tissues. Cervix has a transitional epithelial layer which changes with hormone level of not only Estrogen but also by infection and trauma.

80% Cervical cancer is predominantly seen in ectocervix. Rest are seen in endocervix Squamocolumnar Junction is the meeting point of two epithelial layers. Columnar epithelial lined endo cervix and squamous epithelial lined ectocervix meets at this point. This is a dynamic point in it’s occurrence.

High Risk Types Early sexual exposure (<16 year of age) Multiple Sexual Partners Immunocompromised Age >30 Smoking habits Poor genital hygiene Persistent Genital Infections and STD Dietary deficiency of Vit A, C, E Improper Screening

HPV 16, 18,31,33,45,52,56, 58, 59,68 are high risk strains and HPV type 6,11,42,43,44 are low risk strains Also caused by HSV 2, HIV, Chlamydia like organisms Cervical cancer is commonly associated with Human Papillomavirus infection. Normally 200 plus strain are seen to attack human body. Of which a few only produce significant effects. Our body Host Defense clears the infection and fights back against HPV. But presence of high risk factors and altered immune status of our body can’t combat the persistent infection leading to Cervical cancer. In low vaginal pH, trauma there is a replacement of columnar epithelium at the junction to squamous epithelium occurs. At this point when Carcinogen specially HPV infection occurs there is seen a kind of Atypical metaplasia. Now HPV integrated in human genome leading to expression of oncoproteins & mutation of tumor suppressor genes. Which in future converts into a full grown Invasive Carcinoma of Cervix.

Vaginal bleeding after sex There is vaginal bleeding after menopause Vaginal bleeding between periods Periods are heavier or longer than normal Vaginal discharge when comes is watery and has a peculiar odor or contains blood Experiences pelvic pain or pain during sex Difficult or painful bowel movements Bleeding from the rectum when having a bowel movement Difficulty or Pain during urination or blood in the urine Dull backache Swelling of the lower limbs Cervical cancer can sometimes cause a dull backache or some peculiar sensations of pressure or heaviness in the pelvic region. However, with an early-stage tumor the discomfort is either mild or even unnoticeable.

Usually a Triage of Screening is done with the help of Liquid Based Cytological Evaluation by PAP Smear HPV DNA Hybrid Capture Colposcopy Once Atypical cells are found in PAP Smear it is send for HPV DNA Testing. If it also comes negetive a colposcopic biopsy is taken. If HPV DNA testing comes negetive usually a repeat Smear is done after 5 years Usually Cervical cancer or Carcinoma of Cervix is of three types. Exophytic Ulcerative Infiltrative Most of the Carcinoma of Cervix are Squamous Cell Carcinoma. They arises from the ectocervix.

Procedures used usually are Lymph Node Palpation Colposcopy and Biopsy Hysteroscopy Chest and Skeletal X-Ray CT, MRI, FGD-PET Scan

Prognosis or curability depend on Tumor size, Involvements of Lymph Nodes, Extra Cervical Spread, Invasion in the structures. 4 stages are seen in Cervical cancer. Stage 1, 2, 3 and 4 Usually a Cervical cancer patient dies due to either Uremia, Hemorrhage, Sepsis, Chachexia or Distant Metastasis leading to seeding of tissues in distant organs.

HPV Vaccine already developed from capsid coat of HPV Virus. Cervarix vaccine is active against HPV Types 16 and 18. Gardasil vaccine is active against HPV 6,11,16,18. Vaccine cannot prevent already HPV infection but works well in non infected women. So it is9 ideal to give these vaccine before the sexual activities.Vaccines are effective at least 7.5 years. For female aged less than 15 two dose (0, 6 month )and age more than 15 3 dose (0,1-2,6 month) is the recommended schedule for vaccination against HPV

Cervical cancer causes deaths all over world. In India Carcinoma of Cervix is a major Public Health problem in women and the second most common cause of Gynecological Malignancy. So Cervical Cancer should be properly addressed, discussion with an experienced physician or gynecologist is essential