MedicineSurgicalOrthoPediatricChestCardiac

STIMULATION Based LEARNING | NIGROSTIRAL PATHWAY LESIONS

Learn PHYSIOLOGY · tap a clinical state to see which synapse is lesioned and how it changes motor output and different lesions

INDIRECT PATHWAY DIRECT PATHWAY MOTOR CORTEXglutamate in · final output STRIATUMcaudate + putamen GPi / SubNigRetumain inhibitory output GPeindirect relay SUBTHALAMIC Neu.only excitatory nucleus THALAMUSmotor relay Sub Nig P. Compdopaminergic neurons ×DOPAMINE LOST ×STRIATAL NEURONS LOST ×STN OUTPUT LOST
GABA (inhibitory)
Glutamate (excitatory)
Dopamine
Net motor output
Lesioned synapse
Live clinical state
NORMAL
Balanced direct and indirect pathways. Dopamine facilitates movement via D1/D2 receptors.
Pathway activity
Direct (Str → GPi)70%
Indirect (Str → GPe)50%
Dopamine (SNc)100%
GPi/SNr output55%
NET THALAMOCORTICAL OUTPUT
NORMAL
FACTS TO REMEMBER
Dopamine stimulates D1 (direct, ↑movement) and inhibits D2 (indirect, ↓ braking) receptors on striatal neurons → net facilitation of movement.
Made with ❤️ | Tools © nyyvv.com 🇮🇳
NYYVV | Foundation of Your Good Health
HEALTH HOSPITAL
LABS MEDS
CONSULT